In this talk, we’ll explore the pioneering application of generative pre-trained models, specifically scGPT, to advance cellular biology and genetics research. Leveraging single-cell sequencing data, we’ve constructed scGPT, a foundation model designed to distill biological insights from a repository of over 33 million cells. This approach parallels words forming text to genes defining cells, bridging the gap between technology and biology. The optimized application of scGPT through transfer learning enhances performance across diverse downstream applications, including cell-type annotation, multi-batch integration, and gene network inference. This talk aims to illuminate the transformative potential of such models in cellular biology.
Dr. Bo Wang
Dr. Bo Wang is a tenure-track Assistant Professor in the Departments of Computer Science and Laboratory Medicine & Pathobiology at the University of Toronto. He is the inaugural Temerty Professor in AI Research and Education in Medicine. Dr. Wang is the Chief AI scientist at the University Health Network, the largest research hospital in Canada. He also holds a CIFAR AI Chair at Vector Institute. Dr. Wang obtained his PhD from the Department of Computer Science at Stanford University in 2017. Dr. Wang’s research focuses on machine learning, computational biology, and computer vision, with a particular emphasis on their applications in biomedicine. His significant contributions to these fields have led to his recognition through numerous esteemed awards, including the Gairdner Early Career Researcher Award and the Canada Research Chair Award.
BioSpark Group is a non-profit corporation registered in Massachusetts of the United States. The purpose of BioSpark Group is to establish a biotechnology ecosystem with a collaborative and supportive scholar network, promote leadership and entrepreneurship, and facilitate scientific translation.