2021全球药物结晶
高峰论坛发布最新议程
与利兹大学，MIT、明尼苏达大学等领衔结晶教授、辉瑞、默克、BMS、礼来等公司的结晶专家相约金秋10月，通过赋能技术，突破药物开发瓶颈
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The Center for Pharma Crystallization (CfPC) at J-Star Research, Inc., a subsidiary of Porton Pharma Solutions, is pleased to announce the program of 2nd annual Pharmaceutical Crystallization Summit, to be held on October 14 and 15, 2021, jointly with our partners XtalPi, BlazeMetrics, and Technobis. 博腾股份子公司J-Star Research的药物结晶中心(CfPC)近日宣布，将于2021年10月14日至15日联合晶泰科技、BlazeMetrics和Technobis举办第二届全球药物结晶高峰论坛。
The 2-day event includes 4 sessions, with 12 keynote presentations by leading industrial and academic experts, and 3 topical panel discussions moderated by SMEs from the pharma industry. See topical and speaker details at. 这两天的峰会将采用线上与线下相结合的方式，共有12个主题报告和3个专题讨论，分别由制药行业专家来主持。如需详情，请跳转以下地址：
www.pharmaceuticalcrystallizationsummit.com
Areas of opportunity identified by Enabling Technologies Consortium (ETC) 赋能技术联盟（ETC）确认的潜在发展领域
Crystal structure prediction 晶体结构预测
Crystal shape prediction 晶体形貌预测
Solubility assessment 溶解度评估
Purification 纯化
Analytical technologies 分析技术
Areas of potential innovation identified by National Academies of Sciences, Engineering, and Medicine (NASEM)
美国国家科学工程医药学院（NASEM）确认的潜在创新领域
Co-processed APIs 协同加工API
Process intensification 过程强化
Additive manufacturing 制剂辅料生产
Advanced process control & automation 先进过程控制与自动化
Modular systems 模块化系统
议程安排
（以下时间均为北京时间）
第一天
Friday, October 15, 2021
2021年10月15日星期五
Session 1: Smarter Solid Form & Pre-formulation Studies
论坛1：更智能的固态和处方前制剂研究
Moderator: Dr. Shanming Kuang
主持人：匡善明博士
Dr. Shanming Kuang
Head of Center for Pharma Crystallizationat Shanghai Branch, Porton Pharma Solutions Senior Director of Solid Form Studies, Center for Pharma Crystallization, J-Star Research Inc.
博腾上海药物结晶中心主任/
J-STAR药物结晶中心固态研发高级总监
20:15 – 21:05
Dr. Alfred Lee | Principal Scientist
Merck Research Laboratories
Topic 议题
Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264): A Solid-State Chemistry Perspective
从固态化学角度探讨绿色可持续的Gefapixant枸橼酸（MK-7264）生产工艺的开发
21:05 – 21:55
Dr. Ann Newman
Solid-State and Pharmaceutical Consultant
Seventh Street Development Group
Topic 议题
What Solid Form Should I Choose?
如何选择固体形态？
22:15 – 23:05
Dr. Shawn Yin | Research Fellow
Bristol-Myers Squibb
Topic 议题
Understanding and Controlling the API Form/Powder Property Risks in Drug Substance and Product Processes
理解并控制原料药和成品药工艺过程中关于晶型/粉末特性的风险
23:05 – 23:55
Dr. Jessica Bruhn | Principal Scientist
NanoImaging Services
Chandler Greenwell | Applications Scientist
XtalPi Inc.
Dr. Harsh Shah
Senior Scientist
J-Star Research
Topic 议题
Absolute Structure Determination of API Molecules by MicroED Analysis of Co-Crystals Formed Based on COSMO-RS Prediction
基于COSMO-RS预测制备共晶并用MicroED分析共晶确定原料药分子的绝对结构
Friday, October 15, 2021
2021年10月15日星期五
Session 2: Particle Engineering & DS-DP Co-Processing
论坛2：粒子工程和原料药-成品药协同加工
Moderator: Dr. San Kiang
主持人：江山博士
Dr. San Kiang
Chief Technology Officer
Porton Pharmatech/J-Star Research
重庆博腾药业有限公司/J-STAR
首席技术官
01:05 – 01:55
Dr. Christopher Burcham
Senior Engineering Research Advisor
Eli Lilly and Company
Topic 议题
Examples of Particle Engineering to Improve Patient Outcomes and Product Manufacturing
通过粒子工程帮助患者改善产品生产的几个案例
01:55 – 02:45
Prof. Junbo Gong
School of Chemical Engineering and Technology
Tianjin University
Topic 议题
Crystal habit modifications and spherical crystallization design in solution
溶液中调控晶习和球型结晶设计
03:05 – 03:55
Prof. Changquan Calvin Sun
Professor, Director of Graduate Studies, and Associate Department Head, Department of Pharmaceutics
University of Minnesota
Topic 议题
Challenges and Opportunities in Optimizing Mechanical Properties of Drugs by Incorporating Excipients
加入辅料优化药物力学性能面临的挑战和机遇
03:55 – 04:45
Dr. Jian Wang
SVP, Center for Pharma Crystallization, Porton/J-Star
Topic 议题
Bridging the Gap between Drug Substance and Drug Product Productions via Co-Processing
通过原料药与成品药的协同加工来克服药物生产中的瓶颈问题
第二天
Saturday, October 16, 2021
2021年10月16日，星期六
Session 3: Physical Property Based Crystallization Process Development
论坛3：基于物理属性的结晶工艺研发
Moderator: Dr. Yuriy Abramov
主持人：Yuriy Abramov博士
Dr. Yuriy A.Abramov
VP of Scientific Affairs XtalPi Inc.
Yuriy A.Abramov博士
晶泰科技/科学事务副总裁
20:15 – 21:05
Prof. Kevin J Roberts
Brotherton Professor of Chemical Engineering
University of Leeds
Topic 议题
The Importance of Understanding and Characterising the Physical & Chemical Properties of APIs in the Digital Design of Drug Products
理解并表征原料药理化性质对于成品药数字化设计的重要性
21:05 – 21:55
Prof. Allan Myerson
Professor of the Practice
Massachusetts Institute of Technology
Topic 议题
Continuous Crystallization and Purification:The Role of Impurity Incorporation Mechanism in Non-Equilibrium Processes
连续结晶与纯化：含杂机理对非平衡工艺过程的重要性
22:15 – 23:05
Dr. Samir Kulkarni
Principal Scientist
Pfizer
Topic议题
Co-Crystals Platform to Improve Physical Properties of Early Intermediates during API Manufacturing Process
改善原料药制备工艺中前步中间体物理性质的共晶平台
23:05 – 23:55
Prof. Kenneth Morris
University Professor
Long Island University
Director of the Lachman Institute for Pharmaceutical Analysis
Topic 议题
Correlation of Solubility with the Metastable Limit
溶解度与介稳极限的关联模拟
Saturday, October 16, 2021
2021年10月16日，星期六
Session 4: Topical Panel Discussions
论坛4：专题讨论
Moderator: Dr. Alfred Lee
主持人：Alfred Lee 博士
Dr. Alfred Lee
Principal Scientist
Merck Research Laboratories
01:10 – 01:45
Dr. Alfred Lee
Principal Scientist
Merck Research Laboratories
Topic 议题
Potentials and Technologies to Increase Success Rate of Polymorph Screening
提高晶型筛选成功率的潜力和技术
01:45 – 02:20
Kevin Girard
Associate Research Fellow
Pfizer
Topic 议题
Overcoming Industrial Challenges in Implementation of Crystallization Technologies
克服实施结晶技术面临的工业问题
02:20 – 02:55
Dr. Christopher Burcham
Senior Engineering Research Advisor
Eli Lilly and Company
Topic 议题
Realizing Regulatory Challenges in Applying Crystallization Technologies
克服应用结晶技术面临的监管问题
02:55 – 03:00
Closing Remarks by Chairman, Dr. San Kiang, J-Star Research/Porton
大会主席致闭幕词
San Kiang 博士
博腾/J-STAR
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“Serving the patients with the right DP (drug product) in the fastest way possible requires scientists on the API (active pharmaceutical ingredient) side, and DP side to work hand in hand, not in isolation. The speakers at this conference will demonstrate how this kind of collaboration can lead to experimental and theoretical tools to better understand the fundamentals of APIs, their interaction with excipients, API crystallization and formulation processes.” stated by Dr. San Kiang, CTO of Porton, Chairman of the Pharmaceutical Crystallization Summit.
“为了尽快给患者研发出好的成品药，原料药科学家和成品药科学家应打破孤立携手合作。本次峰会的演讲嘉宾们会有力地说明，如何通过携手合作，融合实践经验和理论技术的边际，来帮助理解原料药的基本原理、原料药与辅料的相互作用以及原料药结晶和配方工艺。”
——本届药物结晶高峰论坛主席、博腾药业CTO江山博士。
“I’m really excited about this year’s Summit. The superb program that is in place will offer in-depth scientific and technical discussions on crystallization technologies, geared towards overcoming hurdles in new drug development programs,” said by Dr. Jian Wang, SVP, CfPC at J-Star Research. “I look forward to meeting both old and new friends in the pharma crystallization field in October.”
“对于今年的峰会，我真的很兴奋。已经准备好的峰会内容将给参会者们提供关于结晶技术的深入科学技术性讨论，旨在攻克新药开发中的难题。我十分期待10月份与药物结晶领域的新老朋友相会。”
——博腾/JSTAR 高级副总裁王建博士。
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Please contact cfpc@jstar-research.com for any question you may have. We look forward to seeing you at the Summit.
如有疑问，请联系 cfpc@jstar-research.com。
我们期待在峰会相见。
Warmly welcome our friends to follow us on this Summit in the coming months.
热烈欢迎大家持续关注。
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